Drug interactions
Metronidazole + Sonidegib
Severity: Moderate
Metronidazole and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may raise sonidegib exposure via CYP3A4 inhibition, increasing musculoskeletal toxicity including rhabdomyolysis risk.
What this interaction means in plain words
Metronidazole and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Sonidegib belongs to Oncology.
Why it happens
CYP3A4 inhibition by metronidazole reduces sonidegib clearance.
What to do
Avoid if possible; if needed, limit metronidazole to under 14 days. Monitor for muscle pain and check creatine kinase if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Metronidazole with Sonidegib?
MediHelp rates the interaction as moderate. Metronidazole and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metronidazole may raise sonidegib exposure via CYP3A4 inhibition, increasing musculoskeletal toxicity including rhabdomyolysis risk.
How serious is the interaction between Metronidazole and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, limit metronidazole to under 14 days. Monitor for muscle pain and check creatine kinase if symptoms arise.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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