Drug interactions
Metronidazole + Tazemetostat
Severity: Minor
Metronidazole and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is metabolized by CYP3A4, and moderate inhibitors raise its exposure. Metronidazole is a weak inhibitor, so a major change is unlikely but higher exposure could increase adverse effects.
What this interaction means in plain words
Metronidazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Tazemetostat belongs to Miscellaneous.
Why it happens
Theoretical weak CYP3A4 inhibition by metronidazole reducing tazemetostat clearance.
What to do
No empirical dose change is needed. Monitor for tazemetostat adverse effects and adjust the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Metronidazole with Tazemetostat?
MediHelp rates the interaction as minor. Metronidazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is metabolized by CYP3A4, and moderate inhibitors raise its exposure. Metronidazole is a weak inhibitor, so a major change is unlikely but higher exposure could increase adverse effects.
How serious is the interaction between Metronidazole and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for tazemetostat adverse effects and adjust the dose if they occur.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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