Drug interactions
Metronidazole + Tipranavir
Severity: Moderate
Metronidazole and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir oral solution and capsules contain alcohol (capsules contain dehydrated alcohol), and metronidazole may cause a disulfiram-like reaction with alcohol. This could cause flushing, nausea, vomiting and palpitations. The CYP3A4 effect of metronidazole on tipranavir is not clinically meaningful.
What this interaction means in plain words
Metronidazole and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metronidazole belongs to Anti Parasitic; Tipranavir belongs to Anti Virals.
Why it happens
Ethanol in the tipranavir formulation combined with metronidazole's proposed impairment of acetaldehyde metabolism.
What to do
Counsel the patient and monitor for disulfiram-like symptoms. Consider an alternative antibacterial or antiretroviral if reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Metronidazole with Tipranavir?
MediHelp rates the interaction as moderate. Metronidazole and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir oral solution and capsules contain alcohol (capsules contain dehydrated alcohol), and metronidazole may cause a disulfiram-like reaction with alcohol. This could cause flushing, nausea, vomiting and palpitations. The CYP3A4 effect of metronidazole on tipranavir is not clinically meaningful.
How serious is the interaction between Metronidazole and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient and monitor for disulfiram-like symptoms. Consider an alternative antibacterial or antiretroviral if reactions occur.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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