Drug interactions
Metronidazole + Voriconazole
Severity: Minor
Metronidazole and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole has been reported to raise voriconazole levels in isolated cases, and both drugs can cause neurotoxicity and QT prolongation. The interaction is uncommon and poorly characterized.
What this interaction means in plain words
Metronidazole and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metronidazole belongs to Anti Parasitic; Voriconazole belongs to Anti Fungals.
Why it happens
Possible inhibition of voriconazole metabolism by metronidazole; the mechanism is not well established.
What to do
Monitor for voriconazole toxicity such as visual or neurologic effects, and check ECG if other QT risks are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metronidazole with Voriconazole?
MediHelp rates the interaction as minor. Metronidazole and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole has been reported to raise voriconazole levels in isolated cases, and both drugs can cause neurotoxicity and QT prolongation. The interaction is uncommon and poorly characterized.
How serious is the interaction between Metronidazole and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for voriconazole toxicity such as visual or neurologic effects, and check ECG if other QT risks are present.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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