Drug interactions
Metyrapone + Prednisolone
Severity: Moderate
Metyrapone and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisolone can interfere with interpretation of metyrapone testing because it suppresses the pituitary-adrenal axis and ACTH. Prednisolone also cross-reacts in some cortisol assays, confounding results.
What this interaction means in plain words
Metyrapone and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metyrapone belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Exogenous glucocorticoid suppresses ACTH via negative feedback, blunting the metyrapone-induced rise in 11-deoxycortisol; assay cross-reactivity may also occur.
What to do
Avoid glucocorticoids before and during metyrapone testing of the adrenal axis where possible. Interpret results in light of steroid exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
Frequently asked questions
Can I take Metyrapone with Prednisolone?
MediHelp rates the interaction as moderate. Metyrapone and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisolone can interfere with interpretation of metyrapone testing because it suppresses the pituitary-adrenal axis and ACTH. Prednisolone also cross-reacts in some cortisol assays, confounding results.
How serious is the interaction between Metyrapone and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid glucocorticoids before and during metyrapone testing of the adrenal axis where possible. Interpret results in light of steroid exposure.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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