Drug interactions
Mexiletine + Pefloxacin
Severity: Moderate
Mexiletine and Pefloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pefloxacin inhibits CYP1A2, which contributes to mexiletine metabolism, so mexiletine levels may increase. Higher exposure can cause neurologic effects and arrhythmias.
What this interaction means in plain words
Mexiletine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mexiletine belongs to Cardiovascular; Pefloxacin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP1A2-mediated mexiletine metabolism by pefloxacin.
What to do
Monitor for mexiletine toxicity and QT or rhythm changes, and reduce the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Pefloxacin
- Pefloxacin + Tizanidine Contraindicated
- Clozapine + Pefloxacin Major
- Duloxetine + Pefloxacin Major
- Pefloxacin + Theophylline Major
- Asenapine + Pefloxacin Moderate
- Caffeine + Pefloxacin Moderate
Frequently asked questions
Can I take Mexiletine with Pefloxacin?
MediHelp rates the interaction as moderate. Mexiletine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pefloxacin inhibits CYP1A2, which contributes to mexiletine metabolism, so mexiletine levels may increase. Higher exposure can cause neurologic effects and arrhythmias.
How serious is the interaction between Mexiletine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mexiletine toxicity and QT or rhythm changes, and reduce the dose if adverse effects occur.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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