Drug interactions
Mexiletine + Pirfenidone
Severity: Moderate
Mexiletine and Pirfenidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirfenidone is cleared mainly by CYP1A2, and mexiletine inhibits this enzyme, so pirfenidone exposure may rise. This can increase nausea, photosensitivity rash and other dose-related adverse effects.
What this interaction means in plain words
Mexiletine and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mexiletine belongs to Cardiovascular; Pirfenidone belongs to Miscellaneous.
Why it happens
Mexiletine inhibits CYP1A2, reducing pirfenidone clearance.
What to do
Monitor for pirfenidone adverse effects and consider reducing the dose or interrupting treatment if they develop; advise sun protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Pirfenidone
Frequently asked questions
Can I take Mexiletine with Pirfenidone?
MediHelp rates the interaction as moderate. Mexiletine and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirfenidone is cleared mainly by CYP1A2, and mexiletine inhibits this enzyme, so pirfenidone exposure may rise. This can increase nausea, photosensitivity rash and other dose-related adverse effects.
How serious is the interaction between Mexiletine and Pirfenidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pirfenidone adverse effects and consider reducing the dose or interrupting treatment if they develop; advise sun protection.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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