Drug interactions
Mexiletine + Rasagiline
Severity: Moderate
Mexiletine and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is cleared mainly by CYP1A2, and mexiletine inhibits this enzyme, which can raise rasagiline exposure. Increased MAO-B inhibitor effect may cause more adverse effects such as orthostatic hypotension and dyskinesia.
What this interaction means in plain words
Mexiletine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mexiletine belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
Why it happens
Mexiletine inhibits CYP1A2 metabolism of rasagiline.
What to do
Limit rasagiline to 0.5 mg daily as labeled for CYP1A2 inhibitors. Monitor blood pressure and for dyskinesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Mexiletine with Rasagiline?
MediHelp rates the interaction as moderate. Mexiletine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is cleared mainly by CYP1A2, and mexiletine inhibits this enzyme, which can raise rasagiline exposure. Increased MAO-B inhibitor effect may cause more adverse effects such as orthostatic hypotension and dyskinesia.
How serious is the interaction between Mexiletine and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit rasagiline to 0.5 mg daily as labeled for CYP1A2 inhibitors. Monitor blood pressure and for dyskinesia.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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