Drug interactions
Mexiletine + Ropinirole
Severity: Moderate
Mexiletine and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ropinirole is cleared mainly by CYP1A2, and mexiletine inhibits this enzyme, which can increase ropinirole concentrations. This can cause somnolence, nausea, dizziness, hypotension, and hallucinations.
What this interaction means in plain words
Mexiletine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mexiletine belongs to Cardiovascular; Ropinirole belongs to Central Nervous System.
Why it happens
Mexiletine inhibits CYP1A2 metabolism of ropinirole.
What to do
Monitor for dopaminergic adverse effects and adjust the ropinirole dose accordingly. Reassess the dose when mexiletine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Mexiletine with Ropinirole?
MediHelp rates the interaction as moderate. Mexiletine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ropinirole is cleared mainly by CYP1A2, and mexiletine inhibits this enzyme, which can increase ropinirole concentrations. This can cause somnolence, nausea, dizziness, hypotension, and hallucinations.
How serious is the interaction between Mexiletine and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dopaminergic adverse effects and adjust the ropinirole dose accordingly. Reassess the dose when mexiletine is started or stopped.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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