Drug interactions
Miconazole + Terbinafine
Severity: Minor
Miconazole and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic miconazole inhibits CYP2C9 and CYP3A4 and may modestly raise terbinafine levels. Using two antifungals together offers little benefit and adds hepatotoxicity risk. Topical miconazole has negligible systemic exposure.
What this interaction means in plain words
Miconazole and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Miconazole belongs to Anti Fungals; Terbinafine belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP2C9 and CYP3A4, which contribute to terbinafine clearance.
What to do
Avoid unnecessary combined systemic antifungal use; monitor liver function if both are given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Miconazole
Frequently asked questions
Can I take Miconazole with Terbinafine?
MediHelp rates the interaction as minor. Miconazole and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic miconazole inhibits CYP2C9 and CYP3A4 and may modestly raise terbinafine levels. Using two antifungals together offers little benefit and adds hepatotoxicity risk. Topical miconazole has negligible systemic exposure.
How serious is the interaction between Miconazole and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary combined systemic antifungal use; monitor liver function if both are given.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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