Drug interactions
Miconazole vaginal + Piroxicam
Severity: Minor
Miconazole vaginal and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has low but measurable systemic absorption and, as an azole, can inhibit CYP2C9, which may modestly increase piroxicam exposure. The effect is most relevant with repeated or prolonged use.
What this interaction means in plain words
Miconazole vaginal and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Systemically absorbed miconazole may inhibit CYP2C9 metabolism of piroxicam.
What to do
No routine change is needed for short courses; watch for gastrointestinal symptoms with prolonged coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Miconazole vaginal with Piroxicam?
MediHelp rates the interaction as minor. Miconazole vaginal and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has low but measurable systemic absorption and, as an azole, can inhibit CYP2C9, which may modestly increase piroxicam exposure. The effect is most relevant with repeated or prolonged use.
How serious is the interaction between Miconazole vaginal and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for short courses; watch for gastrointestinal symptoms with prolonged coadministration.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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