Drug interactions
Miconazole vaginal + Sirolimus
Severity: Minor
Miconazole vaginal and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has low systemic absorption, though rare cases of interactions with CYP substrates have been reported. A clinically important rise in sirolimus levels is unlikely with short courses.
What this interaction means in plain words
Miconazole vaginal and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Miconazole inhibits CYP3A4, but systemic exposure from vaginal use is minimal.
What to do
No routine change is needed; check sirolimus trough levels if prolonged or high-dose vaginal therapy is used or toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Miconazole vaginal and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Miconazole vaginal with Sirolimus?
MediHelp rates the interaction as minor. Miconazole vaginal and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has low systemic absorption, though rare cases of interactions with CYP substrates have been reported. A clinically important rise in sirolimus levels is unlikely with short courses.
How serious is the interaction between Miconazole vaginal and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check sirolimus trough levels if prolonged or high-dose vaginal therapy is used or toxicity appears.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
