Drug interactions
Miconazole vaginal + Tacrolimus
Severity: Minor
Miconazole vaginal and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP3A4 inhibitor and systemic absorption from vaginal use is small but can be present. Rarely, tacrolimus levels may rise, increasing toxicity risk.
What this interaction means in plain words
Miconazole vaginal and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated tacrolimus metabolism by absorbed miconazole.
What to do
Short courses generally need no adjustment; check tacrolimus trough and renal function if prolonged or repeated use occurs or toxicity symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Miconazole vaginal with Tacrolimus?
MediHelp rates the interaction as minor. Miconazole vaginal and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole is a CYP3A4 inhibitor and systemic absorption from vaginal use is small but can be present. Rarely, tacrolimus levels may rise, increasing toxicity risk.
How serious is the interaction between Miconazole vaginal and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Short courses generally need no adjustment; check tacrolimus trough and renal function if prolonged or repeated use occurs or toxicity symptoms appear.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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