Drug interactions
Miconazole vaginal + Voriconazole
Severity: Minor
Miconazole vaginal and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole is minimally absorbed, but it can inhibit CYP2C9 and CYP3A4, and systemic effects have been reported with warfarin. A meaningful rise in voriconazole levels is unlikely.
What this interaction means in plain words
Miconazole vaginal and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Small systemic miconazole exposure may weakly inhibit CYP2C9 and CYP3A4.
What to do
No action is generally needed; monitor for voriconazole adverse effects during prolonged or repeated vaginal miconazole use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Miconazole vaginal with Voriconazole?
MediHelp rates the interaction as minor. Miconazole vaginal and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole is minimally absorbed, but it can inhibit CYP2C9 and CYP3A4, and systemic effects have been reported with warfarin. A meaningful rise in voriconazole levels is unlikely.
How serious is the interaction between Miconazole vaginal and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; monitor for voriconazole adverse effects during prolonged or repeated vaginal miconazole use.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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