Drug interactions
Microbiota + Moxifloxacin
Severity: Moderate
Microbiota and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live microbiota products contain bacterial spores that antibiotics can reduce or destroy, lessening their ability to restore the gut flora. Moxifloxacin has activity against many gut bacteria, so it may reduce the efficacy of the product.
What this interaction means in plain words
Microbiota and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity of moxifloxacin reduces viability or engraftment of the live bacterial product.
What to do
Finish the antibiotic course and allow the interval stated in the product labeling before giving the microbiota product.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Microbiota with Moxifloxacin?
MediHelp rates the interaction as moderate. Microbiota and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live microbiota products contain bacterial spores that antibiotics can reduce or destroy, lessening their ability to restore the gut flora. Moxifloxacin has activity against many gut bacteria, so it may reduce the efficacy of the product.
How serious is the interaction between Microbiota and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Finish the antibiotic course and allow the interval stated in the product labeling before giving the microbiota product.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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