Drug interactions
Microbiota + Nitrofurantoin
Severity: Moderate
Microbiota and Nitrofurantoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota products contain live bacterial spores meant to recolonize the gut after C. difficile infection. Concurrent antibiotics may reduce their viability and efficacy, though nitrofurantoin has limited effect on gut flora.
What this interaction means in plain words
Microbiota and Nitrofurantoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may reduce survival or engraftment of the administered bacterial spores.
What to do
Complete the antibiotic course and allow the interval stated in the product labeling before giving the microbiota product. Avoid starting new antibiotics around dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Microbiota with Nitrofurantoin?
MediHelp rates the interaction as moderate. Microbiota and Nitrofurantoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota products contain live bacterial spores meant to recolonize the gut after C. difficile infection. Concurrent antibiotics may reduce their viability and efficacy, though nitrofurantoin has limited effect on gut flora.
How serious is the interaction between Microbiota and Nitrofurantoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the antibiotic course and allow the interval stated in the product labeling before giving the microbiota product. Avoid starting new antibiotics around dosing.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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