Drug interactions
Midazolam + Mobocertinib
Severity: Moderate
Midazolam and Mobocertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib induces CYP3A4 and may lower midazolam concentrations, reducing sedative or anxiolytic effect. Oral midazolam is particularly affected because of its large first-pass metabolism.
What this interaction means in plain words
Midazolam and Mobocertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mobocertinib induction of CYP3A4 increases the hepatic and intestinal metabolism of midazolam.
What to do
Monitor for reduced midazolam effect and titrate the dose to clinical response, or choose a drug that is not CYP3A4-dependent, such as lorazepam. Follow product labeling for CYP3A substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Midazolam and Mobocertinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Mobocertinib?
MediHelp rates the interaction as moderate. Midazolam and Mobocertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mobocertinib induces CYP3A4 and may lower midazolam concentrations, reducing sedative or anxiolytic effect. Oral midazolam is particularly affected because of its large first-pass metabolism.
How serious is the interaction between Midazolam and Mobocertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced midazolam effect and titrate the dose to clinical response, or choose a drug that is not CYP3A4-dependent, such as lorazepam. Follow product labeling for CYP3A substrates.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
