Drug interactions
Midazolam + Molindone
Severity: Moderate
Midazolam and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Molindone is an antipsychotic with sedative effects, and midazolam adds to CNS depression and may cause hypotension. The risk is greater in the elderly and with higher doses.
What this interaction means in plain words
Midazolam and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine antagonism and GABA-A potentiation.
What to do
Start with lower midazolam doses and monitor sedation, blood pressure and respiration. Avoid additional sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Molindone?
MediHelp rates the interaction as moderate. Midazolam and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Molindone is an antipsychotic with sedative effects, and midazolam adds to CNS depression and may cause hypotension. The risk is greater in the elderly and with higher doses.
How serious is the interaction between Midazolam and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower midazolam doses and monitor sedation, blood pressure and respiration. Avoid additional sedatives where possible.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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