Drug interactions
Midazolam + Motherwort
Severity: Minor
Midazolam and Motherwort: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort is used traditionally as a mild sedative and may add to midazolam drowsiness. Evidence is limited.
What this interaction means in plain words
Midazolam and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Presumed additive sedative effect; mechanism of motherwort is not well established.
What to do
Ask about herbal use and monitor sedation; reduce midazolam dose if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Motherwort?
MediHelp rates the interaction as minor. Midazolam and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort is used traditionally as a mild sedative and may add to midazolam drowsiness. Evidence is limited.
How serious is the interaction between Midazolam and Motherwort?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about herbal use and monitor sedation; reduce midazolam dose if excessive drowsiness occurs.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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