Drug interactions
Midazolam + Nitrous oxide
Severity: Moderate
Midazolam and Nitrous oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrous oxide combined with midazolam deepens sedation and can lead to hypoventilation, airway compromise and hypoxia, particularly in procedural sedation. Lower doses of each drug are often adequate.
What this interaction means in plain words
Midazolam and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression through different anesthetic and sedative pathways.
What to do
Titrate each agent to effect with continuous pulse oximetry and capnography where available. Ensure personnel skilled in airway management are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Nitrous oxide?
MediHelp rates the interaction as moderate. Midazolam and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrous oxide combined with midazolam deepens sedation and can lead to hypoventilation, airway compromise and hypoxia, particularly in procedural sedation. Lower doses of each drug are often adequate.
How serious is the interaction between Midazolam and Nitrous oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate each agent to effect with continuous pulse oximetry and capnography where available. Ensure personnel skilled in airway management are present.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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