Drug interactions
Midazolam + Norepinephrine
Severity: Minor
Midazolam and Norepinephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is a vasopressor and does not meaningfully reverse midazolam sedation. In critically ill patients midazolam can lower blood pressure, and norepinephrine is used to counter this.
What this interaction means in plain words
Midazolam and Norepinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No significant pharmacokinetic or CNS interaction; hemodynamic effects are opposing.
What to do
No adjustment is needed; monitor blood pressure and sedation depth.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Norepinephrine?
MediHelp rates the interaction as minor. Midazolam and Norepinephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Norepinephrine is a vasopressor and does not meaningfully reverse midazolam sedation. In critically ill patients midazolam can lower blood pressure, and norepinephrine is used to counter this.
How serious is the interaction between Midazolam and Norepinephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor blood pressure and sedation depth.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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