Drug interactions
Midazolam + Olopatadine intranasal
Severity: Minor
Midazolam and Olopatadine intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and systemic exposure is low but may add to midazolam sedation. The interaction is generally limited.
What this interaction means in plain words
Midazolam and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression from the antihistamine's sedative effect.
What to do
Advise patients about possible additional drowsiness and monitor sedation after midazolam. No routine dose adjustment is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Olopatadine intranasal?
MediHelp rates the interaction as minor. Midazolam and Olopatadine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal olopatadine can cause somnolence, and systemic exposure is low but may add to midazolam sedation. The interaction is generally limited.
How serious is the interaction between Midazolam and Olopatadine intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about possible additional drowsiness and monitor sedation after midazolam. No routine dose adjustment is required.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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