Drug interactions
Midazolam + Papaveretum
Severity: Major
Midazolam and Papaveretum: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, so combining it with midazolam risks profound sedation and respiratory depression. This is the well-recognized opioid-benzodiazepine hazard.
What this interaction means in plain words
Midazolam and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptors and GABA-A potentiation.
What to do
Reduce doses of both drugs, titrate slowly, and monitor oxygen saturation, respiratory rate and sedation continuously with reversal agents available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Papaveretum?
MediHelp rates the interaction as major. Midazolam and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids including morphine, so combining it with midazolam risks profound sedation and respiratory depression. This is the well-recognized opioid-benzodiazepine hazard.
How serious is the interaction between Midazolam and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses of both drugs, titrate slowly, and monitor oxygen saturation, respiratory rate and sedation continuously with reversal agents available.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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