Drug interactions
Midazolam + Pimozide
Severity: Moderate
Midazolam and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide adds to the sedative effect of midazolam. Pimozide also prolongs the QT interval, so any sedation-related complications or electrolyte disturbance can compound cardiac risk.
What this interaction means in plain words
Midazolam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression; midazolam has no important effect on pimozide QT risk, but pimozide is a sedating antipsychotic.
What to do
Use reduced midazolam doses and monitor sedation and respiration, and keep electrolytes and ECG monitoring in place in patients taking pimozide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Midazolam with Pimozide?
MediHelp rates the interaction as moderate. Midazolam and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide adds to the sedative effect of midazolam. Pimozide also prolongs the QT interval, so any sedation-related complications or electrolyte disturbance can compound cardiac risk.
How serious is the interaction between Midazolam and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced midazolam doses and monitor sedation and respiration, and keep electrolytes and ECG monitoring in place in patients taking pimozide.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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