Drug interactions
Midazolam + Quazepam
Severity: Major
Midazolam and Quazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines taken together produce additive sedation, psychomotor impairment and respiratory depression. Quazepam has long-acting active metabolites, so effects may persist well after dosing.
What this interaction means in plain words
Midazolam and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive positive allosteric modulation of GABA-A receptors by both benzodiazepines.
What to do
Avoid routine concurrent use; if midazolam is needed for procedural sedation, reduce the dose and monitor oxygen saturation and consciousness continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Quazepam?
MediHelp rates the interaction as major. Midazolam and Quazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two benzodiazepines taken together produce additive sedation, psychomotor impairment and respiratory depression. Quazepam has long-acting active metabolites, so effects may persist well after dosing.
How serious is the interaction between Midazolam and Quazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; if midazolam is needed for procedural sedation, reduce the dose and monitor oxygen saturation and consciousness continuously.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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