Drug interactions
Midazolam + Scullcap
Severity: Minor
Midazolam and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is a herbal product traditionally used for its sedative properties and may add to the sedative effect of midazolam. Evidence is limited and largely theoretical.
What this interaction means in plain words
Midazolam and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive GABAergic CNS depression; not well characterized.
What to do
Ask about herbal use before sedation and monitor sedation level; advise patients to avoid combining with sedatives unless directed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Scullcap?
MediHelp rates the interaction as minor. Midazolam and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap is a herbal product traditionally used for its sedative properties and may add to the sedative effect of midazolam. Evidence is limited and largely theoretical.
How serious is the interaction between Midazolam and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about herbal use before sedation and monitor sedation level; advise patients to avoid combining with sedatives unless directed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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