Drug interactions
Midazolam + Selegiline transdermal
Severity: Minor
Midazolam and Selegiline transdermal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline can cause drowsiness and dizziness, and midazolam may add to these effects. Clinically significant interaction is uncommon but additive sedation is possible.
What this interaction means in plain words
Midazolam and Selegiline transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression; selegiline has no major effect on midazolam metabolism.
What to do
Monitor for excess sedation and adjust the midazolam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Selegiline transdermal?
MediHelp rates the interaction as minor. Midazolam and Selegiline transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Transdermal selegiline can cause drowsiness and dizziness, and midazolam may add to these effects. Clinically significant interaction is uncommon but additive sedation is possible.
How serious is the interaction between Midazolam and Selegiline transdermal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and adjust the midazolam dose if needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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