Drug interactions
Midazolam + Sufentanil sl
Severity: Major
Midazolam and Sufentanil sl: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with an opioid can cause profound sedation, respiratory depression, hypotension, coma and death. Regulators carry boxed warnings for this combination.
What this interaction means in plain words
Midazolam and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from benzodiazepine and opioid receptor actions.
What to do
Reserve co-use for patients without alternatives, using the lowest doses and shortest duration. Monitor respiratory rate, oxygen saturation and sedation continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Sufentanil sl?
MediHelp rates the interaction as major. Midazolam and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid can cause profound sedation, respiratory depression, hypotension, coma and death. Regulators carry boxed warnings for this combination.
How serious is the interaction between Midazolam and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve co-use for patients without alternatives, using the lowest doses and shortest duration. Monitor respiratory rate, oxygen saturation and sedation continuously.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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