Drug interactions
Midazolam + Telotristat ethyl
Severity: Moderate
Midazolam and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat ethyl lowers exposure to CYP3A4 substrates, and midazolam levels fell in studies of this combination. Sedative or procedural effects of midazolam may be weaker than expected.
What this interaction means in plain words
Midazolam and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Telotristat ethyl induces CYP3A4, increasing the metabolic clearance of midazolam.
What to do
Monitor for reduced midazolam effect and titrate the dose to response. Consider a higher dose if clinically needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Telotristat ethyl?
MediHelp rates the interaction as moderate. Midazolam and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat ethyl lowers exposure to CYP3A4 substrates, and midazolam levels fell in studies of this combination. Sedative or procedural effects of midazolam may be weaker than expected.
How serious is the interaction between Midazolam and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced midazolam effect and titrate the dose to response. Consider a higher dose if clinically needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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