Drug interactions
Midazolam + Thalidomide
Severity: Moderate
Midazolam and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thalidomide is sedating, and midazolam can add to drowsiness and reduced alertness. The combination may heighten CNS depression.
What this interaction means in plain words
Midazolam and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Thalidomide belongs to Miscellaneous.
Why it happens
Additive CNS depression through independent sedative mechanisms.
What to do
Monitor sedation and use lower midazolam doses. Counsel patients about impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Thalidomide
Frequently asked questions
Can I take Midazolam with Thalidomide?
MediHelp rates the interaction as moderate. Midazolam and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thalidomide is sedating, and midazolam can add to drowsiness and reduced alertness. The combination may heighten CNS depression.
How serious is the interaction between Midazolam and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and use lower midazolam doses. Counsel patients about impaired alertness.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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