Drug interactions
Midazolam + Thiothixene
Severity: Moderate
Midazolam and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is an antipsychotic with sedative properties, and combining it with midazolam can cause additive drowsiness, hypotension and respiratory depression. Caution is greater with parenteral midazolam.
What this interaction means in plain words
Midazolam and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and antipsychotic antihistaminic/alpha-blocking effects.
What to do
Use reduced midazolam doses and monitor sedation, blood pressure and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Thiothixene?
MediHelp rates the interaction as moderate. Midazolam and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is an antipsychotic with sedative properties, and combining it with midazolam can cause additive drowsiness, hypotension and respiratory depression. Caution is greater with parenteral midazolam.
How serious is the interaction between Midazolam and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced midazolam doses and monitor sedation, blood pressure and respiration.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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