Drug interactions
Midazolam + Trifluoperazine
Severity: Moderate
Midazolam and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine and midazolam have additive sedative effects and may cause excess drowsiness, hypotension and respiratory depression. Phenothiazines can also lower seizure threshold.
What this interaction means in plain words
Midazolam and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and phenothiazine dopamine, histamine and adrenergic blockade.
What to do
Start with lower midazolam doses and monitor sedation, blood pressure and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Trifluoperazine?
MediHelp rates the interaction as moderate. Midazolam and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine and midazolam have additive sedative effects and may cause excess drowsiness, hypotension and respiratory depression. Phenothiazines can also lower seizure threshold.
How serious is the interaction between Midazolam and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower midazolam doses and monitor sedation, blood pressure and respiratory status.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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