Drug interactions
Midazolam + Turmeric
Severity: Minor
Midazolam and Turmeric: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Curcumin in turmeric has shown CYP3A4 inhibition in laboratory studies, but clinical evidence of a meaningful rise in midazolam levels is limited. Culinary amounts are unlikely to matter, while concentrated supplements could modestly increase exposure.
What this interaction means in plain words
Midazolam and Turmeric have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of intestinal and hepatic CYP3A4 by curcumin, mainly shown in vitro.
What to do
Ask about turmeric or curcumin supplement use and monitor sedation if midazolam is given, especially orally.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Turmeric?
MediHelp rates the interaction as minor. Midazolam and Turmeric have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Curcumin in turmeric has shown CYP3A4 inhibition in laboratory studies, but clinical evidence of a meaningful rise in midazolam levels is limited. Culinary amounts are unlikely to matter, while concentrated supplements could modestly increase exposure.
How serious is the interaction between Midazolam and Turmeric?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about turmeric or curcumin supplement use and monitor sedation if midazolam is given, especially orally.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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