Drug interactions
Midazolam + Zotepine
Severity: Moderate
Midazolam and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine is a sedating antipsychotic, and combining it with midazolam can produce additive sedation and psychomotor impairment. Zotepine also lowers the seizure threshold and may add to respiratory or hypotensive effects.
What this interaction means in plain words
Midazolam and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and antihistaminic/antiadrenergic effects of zotepine.
What to do
Use the lowest effective midazolam dose and monitor sedation, respiration and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Zotepine?
MediHelp rates the interaction as moderate. Midazolam and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine is a sedating antipsychotic, and combining it with midazolam can produce additive sedation and psychomotor impairment. Zotepine also lowers the seizure threshold and may add to respiratory or hypotensive effects.
How serious is the interaction between Midazolam and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and monitor sedation, respiration and blood pressure.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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