Drug interactions
Midazolam intranasal + Omeprazole
Severity: Minor
Midazolam intranasal and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole is at most a weak CYP3A4 inhibitor and has little effect on midazolam exposure. Any increase in sedation would be small.
What this interaction means in plain words
Midazolam intranasal and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by omeprazole may slightly reduce midazolam clearance.
What to do
No dose change needed. Monitor sedation after the dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Midazolam intranasal with Omeprazole?
MediHelp rates the interaction as minor. Midazolam intranasal and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole is at most a weak CYP3A4 inhibitor and has little effect on midazolam exposure. Any increase in sedation would be small.
How serious is the interaction between Midazolam intranasal and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed. Monitor sedation after the dose.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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