Drug interactions
Mifepristone + Nifedipine
Severity: Moderate
Mifepristone and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a CYP3A4 inhibitor and can raise nifedipine concentrations, causing hypotension, flushing, headache and edema. The effect is greater with prolonged high-dose mifepristone than with single doses.
What this interaction means in plain words
Mifepristone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Nifedipine belongs to Cardiovascular.
Why it happens
Mifepristone inhibits CYP3A4, reducing nifedipine metabolism.
What to do
Monitor blood pressure and use the lowest effective nifedipine dose, particularly during long-term mifepristone therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Nifedipine?
MediHelp rates the interaction as moderate. Mifepristone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone is a CYP3A4 inhibitor and can raise nifedipine concentrations, causing hypotension, flushing, headache and edema. The effect is greater with prolonged high-dose mifepristone than with single doses.
How serious is the interaction between Mifepristone and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and use the lowest effective nifedipine dose, particularly during long-term mifepristone therapy.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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