Drug interactions
Mifepristone + Nilotinib
Severity: Major
Mifepristone and Nilotinib: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a CYP3A4 substrate that prolongs the QT interval in a concentration-dependent way. Mifepristone inhibits CYP3A4 and may itself prolong QT, so combining them raises the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Mifepristone and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of nilotinib, increasing exposure, with possible additive QT prolongation.
What to do
Avoid the combination and choose an alternative. If it must be used, obtain a baseline and follow-up ECG, correct potassium and magnesium, and consider a nilotinib dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Mifepristone with Nilotinib?
MediHelp rates the interaction as major. Mifepristone and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib is a CYP3A4 substrate that prolongs the QT interval in a concentration-dependent way. Mifepristone inhibits CYP3A4 and may itself prolong QT, so combining them raises the risk of torsades de pointes and sudden death.
How serious is the interaction between Mifepristone and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative. If it must be used, obtain a baseline and follow-up ECG, correct potassium and magnesium, and consider a nilotinib dose reduction.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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