Drug interactions
Mifepristone + Norgestrel
Severity: Moderate
Mifepristone and Norgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is an antiprogestogen and can oppose progestin effects, which may reduce the contraceptive reliability of norgestrel. Unplanned pregnancy is a concern, particularly during chronic mifepristone therapy.
What this interaction means in plain words
Mifepristone and Norgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Norgestrel belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism at the progesterone receptor.
What to do
Use a non-hormonal backup contraceptive method during mifepristone therapy. Reassess contraception needs and pregnancy status as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Mifepristone with Norgestrel?
MediHelp rates the interaction as moderate. Mifepristone and Norgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone is an antiprogestogen and can oppose progestin effects, which may reduce the contraceptive reliability of norgestrel. Unplanned pregnancy is a concern, particularly during chronic mifepristone therapy.
How serious is the interaction between Mifepristone and Norgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal backup contraceptive method during mifepristone therapy. Reassess contraception needs and pregnancy status as indicated.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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