Drug interactions
Mifepristone + Pioglitazone
Severity: Moderate
Mifepristone and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP2C8, the main enzyme metabolizing pioglitazone, so pioglitazone exposure may rise. This may increase fluid retention, edema and hypoglycemia.
What this interaction means in plain words
Mifepristone and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Pioglitazone belongs to Endocrine.
Why it happens
CYP2C8 inhibition reduces pioglitazone clearance.
What to do
Monitor glucose and signs of fluid retention, and use the lowest effective pioglitazone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Mifepristone with Pioglitazone?
MediHelp rates the interaction as moderate. Mifepristone and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP2C8, the main enzyme metabolizing pioglitazone, so pioglitazone exposure may rise. This may increase fluid retention, edema and hypoglycemia.
How serious is the interaction between Mifepristone and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and signs of fluid retention, and use the lowest effective pioglitazone dose.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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