Drug interactions
Mifepristone + Praziquantel
Severity: Moderate
Mifepristone and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase praziquantel concentrations by inhibiting its CYP3A4 metabolism. This could amplify praziquantel adverse effects such as dizziness, headache and abdominal discomfort.
What this interaction means in plain words
Mifepristone and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Praziquantel belongs to Anti Parasitic.
Why it happens
Mifepristone inhibits CYP3A4, reducing praziquantel first-pass and systemic clearance.
What to do
Monitor for increased praziquantel adverse effects, particularly CNS effects. Reduce the dose or avoid the combination if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Praziquantel?
MediHelp rates the interaction as moderate. Mifepristone and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may increase praziquantel concentrations by inhibiting its CYP3A4 metabolism. This could amplify praziquantel adverse effects such as dizziness, headache and abdominal discomfort.
How serious is the interaction between Mifepristone and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased praziquantel adverse effects, particularly CNS effects. Reduce the dose or avoid the combination if effects are troublesome.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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