Drug interactions
Mifepristone + Rifabutin
Severity: Moderate
Mifepristone and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is metabolized by CYP3A4, so mifepristone may raise its levels and increase risks such as uveitis, neutropenia and hepatotoxicity. Rifabutin is also a CYP3A4 inducer and may reduce mifepristone exposure.
What this interaction means in plain words
Mifepristone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of rifabutin, while rifabutin induces CYP3A4 and may lower mifepristone levels.
What to do
Monitor for rifabutin toxicity including visual symptoms and blood counts, and consider reducing the rifabutin dose. Watch for reduced mifepristone effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Mifepristone with Rifabutin?
MediHelp rates the interaction as moderate. Mifepristone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin is metabolized by CYP3A4, so mifepristone may raise its levels and increase risks such as uveitis, neutropenia and hepatotoxicity. Rifabutin is also a CYP3A4 inducer and may reduce mifepristone exposure.
How serious is the interaction between Mifepristone and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rifabutin toxicity including visual symptoms and blood counts, and consider reducing the rifabutin dose. Watch for reduced mifepristone effect.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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