Drug interactions
Mifepristone + Salbutamol
Severity: Moderate
Mifepristone and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing's syndrome, can prolong the QT interval. Salbutamol can cause tachycardia and hypokalemia, which may increase the risk of QT-related arrhythmias.
What this interaction means in plain words
Mifepristone and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Salbutamol belongs to Respiratory.
Why it happens
Additive QT-prolonging potential, with salbutamol-induced hypokalemia increasing susceptibility.
What to do
Check potassium and consider an ECG when high-dose or repeated salbutamol is used with long-term mifepristone. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Salbutamol?
MediHelp rates the interaction as moderate. Mifepristone and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone, particularly at the higher doses used for Cushing's syndrome, can prolong the QT interval. Salbutamol can cause tachycardia and hypokalemia, which may increase the risk of QT-related arrhythmias.
How serious is the interaction between Mifepristone and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and consider an ECG when high-dose or repeated salbutamol is used with long-term mifepristone. Correct electrolyte abnormalities.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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