Drug interactions
Mifepristone + Salmeterol
Severity: Moderate
Mifepristone and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, the main enzyme that clears salmeterol, so salmeterol exposure may rise. This can increase cardiovascular effects such as tachycardia, QT prolongation and hypokalemia.
What this interaction means in plain words
Mifepristone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Salmeterol belongs to Respiratory.
Why it happens
CYP3A4 inhibition by mifepristone reduces salmeterol metabolism.
What to do
Monitor heart rate, ECG if symptomatic, and serum potassium, and avoid using higher than recommended salmeterol doses. Consider an alternative bronchodilator if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Salmeterol?
MediHelp rates the interaction as moderate. Mifepristone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4, the main enzyme that clears salmeterol, so salmeterol exposure may rise. This can increase cardiovascular effects such as tachycardia, QT prolongation and hypokalemia.
How serious is the interaction between Mifepristone and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG if symptomatic, and serum potassium, and avoid using higher than recommended salmeterol doses. Consider an alternative bronchodilator if effects emerge.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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