Drug interactions
Mifepristone + Selegiline
Severity: Minor
Mifepristone and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits several CYP enzymes, and selegiline is metabolized partly by CYP2B6 and CYP2C19 among others. Selegiline exposure could rise, though clinical data are lacking.
What this interaction means in plain words
Mifepristone and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
Mifepristone inhibition of CYP2B6/2C-mediated metabolism may reduce selegiline clearance.
What to do
Monitor for increased selegiline effects such as orthostatic hypotension, insomnia or dyskinesia. Reduce the selegiline dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Selegiline?
MediHelp rates the interaction as minor. Mifepristone and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits several CYP enzymes, and selegiline is metabolized partly by CYP2B6 and CYP2C19 among others. Selegiline exposure could rise, though clinical data are lacking.
How serious is the interaction between Mifepristone and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased selegiline effects such as orthostatic hypotension, insomnia or dyskinesia. Reduce the selegiline dose if these occur.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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