Drug interactions
Mifepristone + Sorafenib
Severity: Major
Mifepristone and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and mifepristone inhibits CYP3A4, which may increase sorafenib exposure. Together this raises the risk of QT prolongation and arrhythmia, along with sorafenib toxicities.
What this interaction means in plain words
Mifepristone and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by mifepristone increasing sorafenib levels.
What to do
Prefer an alternative if possible; otherwise obtain a baseline ECG, correct potassium and magnesium, and repeat ECG monitoring. Watch for sorafenib toxicity such as hand-foot reaction, hypertension and diarrhea.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Mifepristone with Sorafenib?
MediHelp rates the interaction as major. Mifepristone and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and mifepristone inhibits CYP3A4, which may increase sorafenib exposure. Together this raises the risk of QT prolongation and arrhythmia, along with sorafenib toxicities.
How serious is the interaction between Mifepristone and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative if possible; otherwise obtain a baseline ECG, correct potassium and magnesium, and repeat ECG monitoring. Watch for sorafenib toxicity such as hand-foot reaction, hypertension and diarrhea.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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