Drug interactions
Mifepristone + Sunitinib
Severity: Major
Mifepristone and Sunitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise sunitinib levels via CYP3A4 inhibition, and both drugs are associated with QT prolongation. The combination therefore increases the risk of arrhythmia and sunitinib toxicity.
What this interaction means in plain words
Mifepristone and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Sunitinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by mifepristone raises sunitinib exposure, plus additive QT prolongation.
What to do
Use an alternative if possible; if combined, monitor ECG and electrolytes and reduce the sunitinib dose based on tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Mifepristone with Sunitinib?
MediHelp rates the interaction as major. Mifepristone and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone may raise sunitinib levels via CYP3A4 inhibition, and both drugs are associated with QT prolongation. The combination therefore increases the risk of arrhythmia and sunitinib toxicity.
How serious is the interaction between Mifepristone and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative if possible; if combined, monitor ECG and electrolytes and reduce the sunitinib dose based on tolerability.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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