Drug interactions
Mifepristone + Tadalafil
Severity: Moderate
Mifepristone and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise tadalafil exposure. Higher tadalafil levels may increase hypotension, headache, flushing and other adverse effects.
What this interaction means in plain words
Mifepristone and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Tadalafil belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated tadalafil metabolism by mifepristone.
What to do
Use the lowest effective tadalafil dose and limit dosing frequency for erectile dysfunction. Avoid use of tadalafil for pulmonary hypertension without close supervision, and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Tadalafil?
MediHelp rates the interaction as moderate. Mifepristone and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise tadalafil exposure. Higher tadalafil levels may increase hypotension, headache, flushing and other adverse effects.
How serious is the interaction between Mifepristone and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective tadalafil dose and limit dosing frequency for erectile dysfunction. Avoid use of tadalafil for pulmonary hypertension without close supervision, and monitor blood pressure.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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