Drug interactions
Mifepristone + Telavancin
Severity: Major
Mifepristone and Telavancin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can prolong the QTc interval, particularly at the higher doses used for Cushing syndrome. Together with telavancin the risk of torsades de pointes may increase.
What this interaction means in plain words
Mifepristone and Telavancin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Telavancin belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Prefer an alternative antibiotic when mifepristone is used at high dose. If co-administration is necessary, obtain ECG monitoring and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Telavancin?
MediHelp rates the interaction as major. Mifepristone and Telavancin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone can prolong the QTc interval, particularly at the higher doses used for Cushing syndrome. Together with telavancin the risk of torsades de pointes may increase.
How serious is the interaction between Mifepristone and Telavancin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic when mifepristone is used at high dose. If co-administration is necessary, obtain ECG monitoring and correct potassium and magnesium.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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