Drug interactions
Mifepristone + Tisotumab vedotin
Severity: Moderate
Mifepristone and Tisotumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic payload MMAE of tisotumab vedotin is a CYP3A4 substrate, and a strong CYP3A4 inhibitor may increase its exposure. This could worsen toxicities such as neutropenia and neuropathy.
What this interaction means in plain words
Mifepristone and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Tisotumab vedotin belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4, reducing clearance of unconjugated MMAE released from the antibody-drug conjugate.
What to do
Monitor for signs of tisotumab vedotin toxicity, including neutropenia, neuropathy and ocular effects. Consider an alternative to mifepristone when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Tisotumab vedotin
- Chloramphenicol + Tisotumab vedotin Moderate
- Clarithromycin + Tisotumab vedotin Moderate
- Itraconazole + Tisotumab vedotin Moderate
- Ketoconazole + Tisotumab vedotin Moderate
- Posaconazole + Tisotumab vedotin Moderate
- Tisotumab vedotin + Voriconazole Moderate
Frequently asked questions
Can I take Mifepristone with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Mifepristone and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload MMAE of tisotumab vedotin is a CYP3A4 substrate, and a strong CYP3A4 inhibitor may increase its exposure. This could worsen toxicities such as neutropenia and neuropathy.
How serious is the interaction between Mifepristone and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of tisotumab vedotin toxicity, including neutropenia, neuropathy and ocular effects. Consider an alternative to mifepristone when feasible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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