Drug interactions
Itraconazole + Tisotumab vedotin
Severity: Moderate
Itraconazole and Tisotumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
What this interaction means in plain words
Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces the metabolism of MMAE.
What to do
Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Tisotumab vedotin
- Chloramphenicol + Tisotumab vedotin Moderate
- Clarithromycin + Tisotumab vedotin Moderate
- Ketoconazole + Tisotumab vedotin Moderate
- Mifepristone + Tisotumab vedotin Moderate
- Posaconazole + Tisotumab vedotin Moderate
- Tisotumab vedotin + Voriconazole Moderate
Frequently asked questions
Can I take Itraconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
How serious is the interaction between Itraconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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